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Buserelin acetate,57982-77-1

Buserelin acetate,57982-77-1
  • CAS#:57982-77-1
  • Product Name:Buserelin acetate
  • Size:1g or more
  • Supply Ability:500g/two weeks
  • FOB Price:Email
  • Payment Terms:T/T
  • Lead time:Within 12 hours after receiving payment
  • Packing:Discreet ways of packing for Customs pass guaranteed
  • Delivery:by express (FedEx,UPS,DHL,EMS), by air
  • Download:MSDS
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  • Specification
  • MSDS
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Scipeptide is a professional Manufacturer, Supplier & Exporter of Buserelin acetate for the pharmaceutical market,Supply Ability:500g/two weeks,we make sure to check this Buserelin acetate chemical on standard quality parameters.

Buserelin acetate-Physiochemical properties

      Sequence(Single-Letter Code):Pyr-HWSY-Ser(tBu)-LRP-NHEt

      Sequence(Three-Letter Code): Glp-His-Trp-Ser-Tyr-Ser(tBu)-Leu-Arg-Pro-NHEt

      Number of residues:     9aa

      Molecular weight:     1239.42g/mol

      Extinction coefficient: 6970 M-1cm-1

      Iso-electric point:    11.2

      Net charge at pH 7:     1.2

      Estimated solubility:     Poor water solubility.

      Storage:store in cool, dry, ventilated place

      PSA:     438.27000

      LogP:     3.12540

      ATC code:L02AE01 QH01CA90

      PubChem     CID: 50225

      IUPHAR/BPS:3860

      DrugBank:DB06719

      UNII:PXW8U3YXDV

      KEGG:

      ChEMBL:1909304

Buserelin acetate Description

      Alternate Names:(d-ser(bu(supt)(sup6)))-lh-rh(1-9)nonapeptide-ethylamide;(d-ser(tbu)(sup6)-ea(sup10))-lhrh;(d-ser(tbu)(sup6)-ea(sup10))-luteinizinghormone-releasinghormon;(d-ser(tbu)(sup6)-ea(sup10))-luteinizinghormone-releasinghormone;d-ser(tbu(sup6))-lh-rh-(1-9)-nonapeptideethylamide;d-ser-(tbu)(sup6)-lhrh-ethylamide;etilamide;hoe766a,Etilamide; Profact; 57982-77-1; HOE 766; ICI 123215

Buserelin is a synthetic analog of gonadotropin-releasing hormone (GnRH). Buserelin binds to and activates pituitary gonadotropin releasing hormone (GnRH) receptors. Prolonged administration of buserelin results in sustained inhibition of gonadotropin production, suppression of testicular and ovarian steroidogenesis, and reduced levels of circulating gonadotropin and gonadal steroids. Buserelin is more potent that GnRH. (NCI04)

Buserelin acetate Application

BUSERELIN is a potent synthetic analog of GONADOTROPIN-RELEASING HORMONE with D-serine substitution at residue 6, glycine10 deletion, and other modifications.

Buserelin acetate References

1. Gonadotropin-releasing hormone receptor concentration differentially regulates intracellular signaling pathways in GGH3 cells.
J H Pinter et. al,Pituitary, 2(3), 181-190 (1999)
2. Effects of gonadotropin-releasing hormone agonist on the incidence of apoptosis in porcine and human granulosa cells.
S Zhao et. al,Gynecologic and Obstetric Investigation, 49(1), 52-56 (2000)
3. Endogenous estrogens lower plasma PCSK9 and LDL cholesterol but not Lp(a) or bile acid synthesis in women.
Lena Persson et. al,Arteriosclerosis, Thrombosis, and Vascular Biology, 32(3), 810-814 (2012)


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