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Desmopressin Acetate (16789-98-3)

Desmopressin Acetate (16789-98-3)
  • CAS#:16789-98-3
  • Product Name:Desmopressin Acetate
  • Size:1g or more
  • Supply Ability:500g/two weeks
  • FOB Price:Email
  • Payment Terms:T/T
  • Lead time:Within 12 hours after receiving payment
  • Packing:Discreet ways of packing for Customs pass guaranteed
  • Delivery:by express (FedEx,UPS,DHL,EMS), by air
  • Download:MSDS
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  • Specification
  • MSDS
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Desmopressin Acetate-Physiochemical properties

      Alternate Names:DDAVP, 1-Deamino-8-D-arginine-vasopressin diacetate, 1-(3-Mercaptopropionic acid)-8-D-arginine-vasopressin diacetate

      Sequence(Three-Letter Code): 3-Mercaptopropionyl-Tyr-Phe-Gln-Asn-Cys-Pro-D-Arg-Gly-NH2 (Disulfide Bridge:1-6)

      Molecular Formula: C46H64N14O12S2

      Molecular weight: 1189.32 g/mol

      Storage:store in cool, dry, ventilated place

Desmopressin Acetate Certifocation of Analysis

Appearance: White or almost white powder
Solubility: Soluble in water and in dilute
Solution of acetic adid and of ethanol
Mass Spectrometry: 1069.2±1
Amimo Acid Content: Asp:0.95-1.05
Glu:0.95-1.05
Pro:0.95-1.05
Gly:0.95-1.05
Cys:0.95-1.05
Tyr: 0.95-1.05
Phe: 0.95-1.05
Arg: 0.95-1.05
No presents other amino acids
HPLC purity: 98.5%
Largest Single Impurity: 0.50%
Peptide content: 95.0%-105.0%
Water Content(K.F): 6.0%
Specific optical rotation: -82.0°-78.0°
Bacterial Endotoxins: <500EU/mg

Desmopressin Acetate Description

      Desmopressin (trade names: DDAVP, DesmoMelt, Minirin, Minirin Melt, Octim, Stimate) is a synthetic replacement for vasopressin, the hormone that reduces urine production. It may be taken nasally, intravenously, or as an oral or sublingual tablet. Physicians prescribe desmopressin most frequently for treatment of diabetes insipidus, bedwetting, or nocturia.

Desmopressin Acetate Application

    Doctors prescribe desmopressin frequently for treatment of nocturnal enuresis (bedwetting). It is usually prescribed in the form of oral desmopressin acetate, DDAVP. Patients taking DDAVP are 4.5 times more likely to sleep without disruption compared with placebo.
Desmopressin can be used to promote the release of von Willebrand factor (with subsequent increase in factor VIII survival secondary to vWF complexing) in patients with coagulation disorders such as von Willebrand disease, mild hemophilia A (factor VIII deficiency), and thrombocytopenia. It can be used with uremic induced platelet dysfunction. It is not effective in the treatment of hemophilia B (factor IX deficiency), severe hemophilia A, or von Willebrand 2B.
Desmopressin is used in the treatment of central diabetes insipidus (DI), to replace endogenous ADH that is missing in the central nervous system type of this disorder (decreased production of ADH from the posterior pituitary). It is also used in the diagnostic workup for diabetes insipidus, in order to distinguish central from nephrogenic DI.

Desmopressin Acetate Reference

1. Leissinger C, Becton D, Cornell C Jr, Cox Gill J. High-dose DDAVP intranasal spray (Stimate) for the prevention and treatment of bleeding in patients with mild haemophilia A, mild or moderate type 1 von Willebrand disease and symptomatic carriers of haemophilia A. Haemophilia 2001;7:258-66. PMID 11380629.

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