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Icatibant acetate,138614-30-9

Icatibant acetate,138614-30-9
  • CAS#:138614-30-9
  • Product Name:Icatibant acetate
  • Size:1g or more
  • Supply Ability:500g/two weeks
  • FOB Price:Email
  • Payment Terms:T/T
  • Lead time:Within 12 hours after receiving payment
  • Packing:Discreet ways of packing for Customs pass guaranteed
  • Delivery:by express (FedEx,UPS,DHL,EMS), by air
  • Download:MSDS
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  • Specification
  • MSDS
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Scipeptide is a professional Manufacturer, Supplier & Exporter of Icatibant acetate for the pharmaceutical market,Supply Ability:500g/two weeks,we make sure to check this Icatibant acetate chemical on standard quality parameters.

Icatibant acetate-Physiochemical properties

      Sequence(Single-Letter Code):(d)RRP-Hyp-G-Thi-S-(d)Tic-Oic-R

      Sequence(Three-Letter Code): H-D-Arg-Arg-Pro-Hyp-Gly-Thi-Ser-D-Tic-Oic-Arg-OH

      Number of residues:     10aa

      Molecular weight:     1364.59g/mol

      Extinction coefficient:  M-1cm-1

      Iso-electric point:   

      Net charge at pH 7:    

      Estimated solubility:     Poor water solubility.

      Storage:store in cool, dry, ventilated place

      PSA:     581.76000

      LogP:     1.67610

      ATC code:B06AC02

      PubChem     CID: 71364






Icatibant acetate Description

      Alternate Names:HOE 140 SYNTHETIC >99% SELECTIVE B2 BRAD YKIN;d-arg-l-arg-l-pro-l-hyp-gly-l-(2-thienyl)ala-l-ser-d-1,2,3,4-tetrahydro-3-isoquinolinecarbonyl-l-(2α,3β,7aβ)-octahydro-1h-indole-2-carbonyl-l-arg;Icatibant acetate, D-Arg-L-Arg-L-Pro-L-Hyp-Gly-L-(2-thienyl)Ala-L-Ser-D-1,2,3,4-tetrahydro-3-isoquinolinecarbonyl-L-(2α,3β,7aβ)-octahydro-1H-indole-2-carbonyl-L-Arg;Firazyr

Icatibant (Firazyr) is a synthetic peptidomimetic drug consisting of ten amino acids, and acts as an effective and specific antagonist of bradykinin B2 receptors. It has been approved in the EU for use in hereditary angioedema, and is under investigation for a number of other conditions in which bradykinin is thought to play a significant role. Icatibant currently has orphan drug status in the United States and FDA approved on August 25, 2011.

Icatibant acetate Application

BUSERELIN is a potent synthetic analog of GONADOTROPIN-RELEASING HORMONE with D-serine substitution at residue 6, glycine10 deletion, and other modifications.

Icatibant acetate References

1. Gonadotropin-releasing hormone receptor concentration differentially regulates intracellular signaling pathways in GGH3 cells.
J H Pinter et. al,Pituitary, 2(3), 181-190 (1999)
2. Effects of gonadotropin-releasing hormone agonist on the incidence of apoptosis in porcine and human granulosa cells.
S Zhao et. al,Gynecologic and Obstetric Investigation, 49(1), 52-56 (2000)
3. Endogenous estrogens lower plasma PCSK9 and LDL cholesterol but not Lp(a) or bile acid synthesis in women.
Lena Persson et. al,Arteriosclerosis, Thrombosis, and Vascular Biology, 32(3), 810-814 (2012)

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