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Octreotide Acetate,83150-76-9

Octreotide Acetate,83150-76-9

     

  • CAS#:83150-76-9
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  • Product Name:Octreotide Acetate
  • Size:1g or more
  • Supply Ability:500g/two weeks
  • FOB Price:Email
  • Payment Terms:T/T
  • Lead time:Within 12 hours after receiving payment
  • Packing:Discreet ways of packing for Customs pass guaranteed
  • Delivery:by express (FedEx,UPS,DHL,EMS), by air
  • Download:MSDS
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Octreotide Acetate-Physiochemical properties

      Sequence(Single-Letter Code): (d)FCF(d)WKTCT-ol,(Disulfide bond)

      Sequence(Three-Letter Code): H-D-Phe-Cys-Phe-D-Trp-Lys-Thr-Cys-L-threoninol,(Disulfide bond)

      Molecular Formula: C49H66N10O10S2

      Molecular weight: 1019.24 g/mol

      Storage:store in cool, dry, ventilated place

      PSA:     382.82000

      LogP:     3.02100

Octreotide Acetate Description

      Alternate Names:Octreotide AcetateDARAMONOL;L-cysteinamide, D-phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-(2-hydroxy-1-(hydroxymethyl) propyl)-cyclic (2->7)-disulfide, (R-(R*,R*));ctreotide;Ocetreotide, Acetate;L-Cysteinamide, D-phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-(1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl-, cyclic (2?7)-disulfide;OXTREOTIDE;[R-(R*,R*)]-D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-[2-hydroxy-1-(hydroxy-methyl)propyl]-cysteinamide cyclic(2->7)-disulfide;Octreotide acetate,SMS 201995; Sandostatin

Octreotide Acetate is a longer acting synthetic octapeptide analog of naturally occurring somatostatin. Octreotide Acetate inhibits the secretion of gastro-entero-pancreatic peptide hormones and the release of growth hormone. Octreotide reduces gastrointestinal motility and inhibits contraction of the gall bladder.

Octreotide acetate (Sandostatin) is an octapeptide congener of native somatostatin, inhibits the secretion of insulin and glucagon. It reduces production of IGF-1 and IGF-2 by the liver by modulation of growth-hormone secretion from the pituitary gland. [1]
The insulin-like growth factors IGF-1 and IGF-2, endogenously produced polypeptide hormones and potent stimulators of cell proliferation, are under investigation as clinical targets in prostate cancer.
Octreotide acetate decreased the urinary excretion of uric acid as well as the plasma concentrations of glucagon and insulin. Octreotide acetate decreased the urinary excretion of sodium and chloride without significiant influence on creatinine clearance, while the concentrations of lactic acid, pyruvic acid in blood, and cyclic AMP in plasma were not changed. [1]

Octreotide Acetate Application

Acromegaly
Carcinoid syndrome
VIPomas

 Octreotide Acetate References

[1] Tetsuya yamamoto, Yuji moriwaki et al. Effect of Octreotide acetate on the Plasma Concentration and Urinary Excretion of Uridine and Purine Bases. Endocrine Journal 2002, 49(2),139-144.

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