Acetato de Eptifibatida, 148031-34-9

Eptifibatide Acetate-Physiochemical properties

Sequence(Single-Letter Code): Map-KGDWPC -Amide,(Disulfide bond)

Sequence(Three-Letter Code): MAP-Lys-Gly-Asp-Trp-Pro-Cys-Amide,(Disulfide bond)

Molecular Formula: C35H49N11O9S2

Peso molecular: 831.962 g / mol

Armazenamento: armazenar em local fresco, seco e ventilado

PSA: 374.49000

LogP: 1.62840

RTECS: HA0849000

PubChem CID: 123610

MDL Number: MFCD05662245

Beilstein Registry: 9608167

SMILES: C1CC2C(=O)NC(CSSCCC(=O)NC(C(=O)NCC(=O)NC(C(=O)NC(C(=O)N2C1)CC3=CNC4=CC=CC=C4 3)CC(=O)O)CCCCN=C(N)N)C(=O)N

Eptifibatide Acetate Description

Alternate Names:MAP-LYS-GLY-ASP-TRP-PRO-CYS-NH2;INTEGRELIN;Eptifibatide;N6-(Aminoiminomethyl)-N2-(3-mercapto-1-oxopropyl-L-lysylglycyl-L-a-aspartyl-L-tryptophyl-L-prolyl-L-cysteinamide;Intrifiban;N6-(AMinoiMinoMethyl)-N2-(3-Mercapto-1-oxopropyl)-L-lysylglycyl-L-.alpha.-aspartyl-L-tryptophyl-L-prolyl-L-cysteinaMide Cyclic (16)-Disulfide;3-Mercaptopropionyl-HoMoarg-Gly-Asp-Trp-Pro-Cys-NH2

Eptifibatide is a specific inhibitor of fibrinogen binding to the platelet membrane integrin glycoprotein GPIIb/IIIa receptor, preventing platelet aggregation. Eptifibatide binds reversibly and competitively.

Eptifibatide Acetate Application

Eptifibatide is an antiplatelet drug of the glycoprotein IIb/IIIa inhibitor class. Eptifibatide is a cyclic heptapeptide derived from a protein found in the venom of the southeastern pygmy rattlesnake (Sistrurus miliarius barbouri). It belongs to the class of the so called arginin-glycin-aspartat-mimetics and reversibly binds to platelets. Eptifibatide has a short half-life. The drug is the third inhibitor of GPIIb/IIIa that has found broad acceptance after the specific antibody abciximab and the non-peptide tirofiban entered the global market.

Eptifibatide Acetate References

1. Plosker, G.L., et al. 2003. Pharmacoeconomics. 21: 885-912. PMID: 12908844

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