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Acetato de goserelina, 145781-92-6

Acetato de goserelina, 145781-92-6
  • CAS #:145781-92-6
  • Nome do produto:Acetato de goserelina
  • Tamanho:1g ou mais
  • Habilidade da fonte:500g / duas semanas
  • FOB Preço:Email
  • Condições de pagamento:T / T
  • Prazo de execução:Dentro de 12 horas após o recebimento do pagamento
  • Embalagem:Maneiras discretas de embalagem para passe alfandegário garantidas
  • Entrega:por expresso (FedEx, UPS, DHL, EMS), por via aérea
  • Download:MSDS
  • Contate agora
  • Especificação
  • MSDS
  • Comentários

Scipeptide is a professional Manufacturer, Supplier & Exporter of Goserelin acetate for the pharmaceutical market,Supply Ability:500g/two weeks,we make sure to check this Goserelin acetate chemical on standard quality parameters.

Goserelin acetate-Physiochemical properties

Sequence(Single-Letter Code):Pyr-HWSY-D-Ser(tBu)-LRP-Aza-Gly-NH2

Sequence(Three-Letter Code): Pyr-His-Trp-Ser-Tyr-D-Ser(tBu)-Leu-Arg-Pro-Aza-Gly-NH2

Número de resíduos: 10aa

Peso molecular: 1269.41g / mol

Coeficiente de extinção: 0 M-1cm-1

Ponto de isolação eletrica:

Carga líquida em pH 7:

Solubilidade estimada: Baixa solubilidade em água.

Armazenamento: armazenar em local fresco, seco e ventilado

PSA: 493.39000

LogP: 2.78000

ATC code:L02AE03

PubChem CID: 5311128

IUPHAR / BPS: 3879

DrugBank: DB00014

UNII:0F65R8P09N

KEGG: D04405

ChEMBL: 1201247

Goserelin acetate Description

Alternate Names:PYR-HIS-TRP-SER-TYR-D-SER(TBU)-LEU-ARG-PRO-AZAGLY-NH2;[(T-BU)DSER6, (AZA)GLY10]-LH-RH;[(T-BU)DSER6, (AZA)GLY10]-LUTEINIZING HORMONE-RELEASING HORMONE;GLP-HIS-TRP-SER-TYR-D-SER(TBU)-LEU-ARG-PRO-AZA-GLY-NH2;(D-SER(TBU)6,AZAGLY10)-LHRH;(D-Ser(tBu)6,Azagly10)-LHRH acetate salt;Goserelin HCl;GOSERELIN HCL[PYR-HIS-TRP-SER-TYR-D-SER(T-BU)-LEU-ARG-PRO-AZAGLY-NH2],Goserelin; Zoladex; ICI 118630; ICI-118630; Decapeptide I

Goserelin is a synthetic decapeptide analog of luteinizing hormone-releasing hormone (LHRH) with antineoplastic activity. Goserelin binds to and activates pituitary gonadotropin releasing hormone (GnRH) receptors. Prolonged administration of goserelin inhibits the secretion of pituitary gonadotropin, thereby decreasing levels of testosterone (in males) and estradiol (in females). Administration of this agent in a depot formulation may result in the regression of sex hormone-sensitive tumors and a reduction in sex organ size and function. (NCI04)

Goserelin implant is used in combination with radiation therapy and other medications to treat localized prostate cancer and is used alone to treat the symptoms associated with advanced prostate cancer. It is also used to treat advanced breast cancer in certain women. It is also used to manage endometriosis (a condition in which the type of tissue that lines the uterus [womb] grows in other areas of the body and causes pain, heavy or irregular menstruation [periods], and other symptoms) and to help with the treatment of abnormal bleeding of the uterus. Goserelin implant is in a class of medications called gonadotropin-releasing hormone (GnRH) agonists. It works by decreasing the amount of certain hormones in the body.

Goserelin acetate Application

A synthetic long-acting agonist of GONADOTROPIN-RELEASING HORMONE. Goserelin is used in treatments of malignant NEOPLASMS of the prostate, uterine fibromas, and metastatic breast cancer.

Goserelin acetate References

1,Kotake, Toshihiko; Michiyuki Usami et al. (August 1999). "Goserelin Acetate with or without Antiandrogen or Estrogen in the Treatment of Patients with Advanced Prostate Cancer: a Multicenter, Randomized, Controlled Trial in Japan". Japanese Journal of Clin. Oncol. 29 (11): 562–570. doi:10.1093/jjco/29.11.562. ISSN 1465-3621. PMID 10678560. Retrieved 2007-02-26.
2,Dittrich R, Binder H, Cupisti S, Hoffmann I, Beckmann MW, Mueller A. Endocrine treatment of male-to-female transsexuals using gonadotropin-releasing hormone agonist. Exp Clin Endocrinol Diabetes 2005;113:586–92.


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