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Acetato de terlipressina, 14636-12-5

Acetato de terlipressina, 14636-12-5
  • CAS #:14636-12-5
  • Nome do produto:Acetato de Terlipressina
  • Tamanho:1g ou mais
  • Habilidade da fonte:500g / duas semanas
  • FOB Preço:Email
  • Condições de pagamento:T / T
  • Prazo de execução:Dentro de 12 horas após o recebimento do pagamento
  • Embalagem:Maneiras discretas de embalagem para passe alfandegário garantidas
  • Entrega:por expresso (FedEx, UPS, DHL, EMS), por via aérea
  • Download:MSDS
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Terlipressin Acetate-Physiochemical properties

Sequence(Single-Letter Code): GGGCYFQNCPKG-NH2 (Disulfide bond)

Sequence(Three-Letter Code): H-Gly - Gly - Gly - Cys - Tyr - Phe - Gln - Asn - Cys - Pro - Lys - Gly -NH2 (Disulfide bond)

Número de resíduos: 12aa

Peso molecular: 1227.37 g / mol

Coeficiente de extinção: 1280 M-1cm-1

Ponto isoelétrico: pH 9.05

Carga líquida em pH 7: 1.9

Solubilidade estimada: Baixa solubilidade em água.

Armazenamento: armazenar em local fresco, seco e ventilado

PSA: 563.45000

LogP: 0.05740

EINECS: 238-680-8

PubChem CID: 72081

Terlipressin Acetate Description

Alternate Names:Terlipressin Acetate,TERLIPRESSIN;TERLIPRESSIN ACETATE;Terilipressin;Gly-Gly-Gly-Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Lys-Gly-NH2 (disulfide bridge 4:9);(2S)-1-[(4S,7S,10S,13S,16S,19S)-19-[[2-[[2-[(2-Aminoacetyl)amino]acetyl]amino]acetyl]amino]-13-benzyl-10-(2-carbamoylethyl)-7-(carbamoylmethyl)-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]-N-[(1S)-5-amino-1-(carbamoylmethylcarbamoyl)pentyl]pyrrolidine-2-carboxamide;N-(N-(N-Glycylglycyl)glycyl)-8-L-lysinevasopressin;N-(GLYCYLGLYCYLGLYCYL)-8-L-LYSINE-VASOPRESSIN;H-Gly-Gly-Gly-Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Lys-Gly-NH2 acetate salt (Disulfide bond),Glypressin; Lucassin; Terlipressinum

Terlipressin is similar to a naturally occurring hormone present in the body, known as antidiuretic hormone (ADH) or vasopressin and contains 12 amino acids. [1]Terlipressin is an analogue of vasopressin used as a vasoactive drug in the management of hypotension. It has been found to be effective when norepinephrine does not help. [2][3] Terlipressin is also a nonselective agonist of V1 vasopressin receptors, but it has a longer half-life and a lower incidence of ischaemic complications

Terlipressin is a synthetic analog of vasopressin and is used as a vasoactive drug in the management of hypotension. Terlipressin represents a prodrug, it is converted to (Lys8)- vasopressin (LVP) after removal of the N-terminal triglycine in vivo. Terlipressin has a longer duration of action and a better safety profile than the parent compound LVP.

Terlipressin Acetate Application

Acute variceal hemorrhage (esophageal varices)
Hepatorenal syndrome
Norepinephrine- resistant septic shock - not yet an approved application

Terlipressin Acetate References

1,Krag A et al. Am J Physiol Renal Physiol. 2008 Nov;295(5):F1295-300



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