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Terlipressin Acetate,14636-12-5

Terlipressin Acetate,14636-12-5
  • CAS#:14636-12-5
  • Product Name:Terlipressin Acetate
  • Size:1g or more
  • Supply Ability:500g/two weeks
  • FOB Price:Email
  • Payment Terms:T/T
  • Lead time:Within 12 hours after receiving payment
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  • Delivery:by express (FedEx,UPS,DHL,EMS), by air
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Terlipressin Acetate-Physiochemical properties

      Sequence(Single-Letter Code): GGGCYFQNCPKG-NH2 (Disulfide bond)

      Sequence(Three-Letter Code): H-Gly - Gly - Gly - Cys - Tyr - Phe - Gln - Asn - Cys - Pro - Lys - Gly -NH2 (Disulfide bond)

      Number of residues:     12aa

      Molecular weight:     1227.37 g/mol

      Extinction coefficient: 1280 M-1cm-1

      Iso-electric point:     pH 9.05

      Net charge at pH 7:     1.9

      Estimated solubility:     Poor water solubility.

      Storage:store in cool, dry, ventilated place

      PSA:     563.45000

      LogP:     0.05740

      EINECS:    238-680-8

      PubChem CID:    72081

Terlipressin Acetate Description

      Alternate Names:Terlipressin Acetate,TERLIPRESSIN;TERLIPRESSIN ACETATE;Terilipressin;Gly-Gly-Gly-Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Lys-Gly-NH2 (disulfide bridge 4:9);(2S)-1-[(4S,7S,10S,13S,16S,19S)-19-[[2-[[2-[(2-Aminoacetyl)amino]acetyl]amino]acetyl]amino]-13-benzyl-10-(2-carbamoylethyl)-7-(carbamoylmethyl)-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]-N-[(1S)-5-amino-1-(carbamoylmethylcarbamoyl)pentyl]pyrrolidine-2-carboxamide;N-(N-(N-Glycylglycyl)glycyl)-8-L-lysinevasopressin;N-(GLYCYLGLYCYLGLYCYL)-8-L-LYSINE-VASOPRESSIN;H-Gly-Gly-Gly-Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Lys-Gly-NH2 acetate salt (Disulfide bond),Glypressin; Lucassin; Terlipressinum

Terlipressin is similar to a naturally occurring hormone present in the body, known as antidiuretic hormone (ADH) or vasopressin and contains 12 amino acids. [1]Terlipressin is an analogue of vasopressin used as a vasoactive drug in the management of hypotension. It has been found to be effective when norepinephrine does not help. [2][3] Terlipressin is also a nonselective agonist of V1 vasopressin receptors, but it has a longer half-life and a lower incidence of ischaemic complications

Terlipressin is a synthetic analog of vasopressin and is used as a vasoactive drug in the management of hypotension. Terlipressin represents a prodrug, it is converted to (Lys8)- vasopressin (LVP) after removal of the N-terminal triglycine in vivo. Terlipressin has a longer duration of action and a better safety profile than the parent compound LVP.

Terlipressin Acetate Application

Acute variceal hemorrhage (esophageal varices)
Hepatorenal syndrome
Norepinephrine- resistant septic shock - not yet an approved application

Terlipressin Acetate References

1,Krag A et al. Am J Physiol Renal Physiol. 2008 Nov;295(5):F1295-300

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